Based on the intelligent collaborative regulation concept of AGC load instructions, intelligent combustion systems and environmental protection island, the optimized control is deployed with variable prediction models and outlet concentration feedback.A monitoring module for the inlet flow field of the denitration reactor was constructed to achieve continuous monitoring of the SCR inlet flow field, deviation early warning, and automatic associated combustion adjustment (intelligent ash blowing) forcorrection. A catalyst activity analysis module, a poisoning analysis and diagnosis module, and an intelligent false poisoning handling module have been constructed to achieve continuous monitoring, analysis and diagnosis of catalyst characteristics.The "Matrix scanning Small zone Monitoring Technology" was constructed, enabling precise and continuous monitoring of ammonia escape and NOx distribution in the denitration outlet flue, effectively supporting the accurate integral control of the "feedbackcontrol loop".